Nai-Wei Yao1, Chen-Tung Yen2, Jeou-Yuan Chen1, and Chen Chang1
1Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan, 2Department of Life Science, National Taiwan University, Taipei, Taiwan
Angiogenesis is a well-known cancer hallmark, which dominates the prognosis
and outcome of cancer patients. To establish rational treatment by targeting
angiogenesis tailored to glioma patients, in this study, we examined the role
of angiogenesis in the pathogenic development of glioma using rat C6 glioma models
in Wistar and Sprague-Dawley (SD) rats. By immunohistochemistry and
multi-parametric MRI methods, we show that C6 gliomas developed in the SD rats
were characterized with enlarged tumors and with shorter survival. The
increased tumor growth in SD rats was associated with increased angiogenesis,
higher levels of HIF-1 and VEGF expression, and the polarization of the
pro-tumorigenic M2 macrophages.
