Abstract #2378

Towards low power EPR Imaging using Frank poly-phase pulse sequence

Nallathamby Devasahayam¹, Randall H. Pursley², Thomas J. Pohida², Shingo Matsumoto³, Keita Saito⁴, Sankaran Subramanian⁵, and Murali C. Krishna⁴

¹Radiation Biology Branch, National Cancer Institute, Bethesda, MD, United States, ²Center for Information Technology, Bethesda, MD, United States, ³Graduate School of Information Science and Technology, Sapporo, Japan, ⁴National Cancer Institute, Bethesda, MD, United States, ⁵Indian Institute of Technology Madras, Chennai, India

Electron Paramagnetic Resonance (EPR) imaging is suited well for small animal physiological imaging with its unique capability of generating in vivo quantitative oxygen maps. The main bottleneck in scaling up pulsed EPR imaging to human anatomy is that the required RF power of US federal food and drug administration (FDA), specific absorption rate (SAR) limits. In Frank Sequence we are using power levels on the order of 250 microwatts in a crossed coil resonator with ~35 dB isolation. Using a 256 pulse polyphase Frank Sequence, it was possible to obtain images with good SNR.

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