Abstract #2377

Tissue correction strategy impacts GABA quantification: a study in healthy aging

Ashley D Harris^1,2,3,4, Eric Porges⁵, Adam J Woods^5,6, Damon G Lamb^5,7, Ronald A Cohen⁵, John B Williamson^5,8, Nicolaas AJ Puts^3,4, and Richard AE Edden^3,4

¹Radiology, University of Calgary, Calgary, AB, Canada, ²CAIR Program, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, ³Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ⁴FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States, ⁶Department of Neuroscience, University of Florida, Gainesville, FL, United States, ⁷Brain Rehabilitation and Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, United States, ⁸Brain Rehabilitation and Research Center, Brain Rehabilitation and Research Center, Gainesville, FL, United States

There are various strategies for tissue correction for MRS. Here, using data from a healthy aging cohort, we show that the selection of tissue correction method can change the conclusions that are drawn from data.

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