Abstract #2092

Early Assessment of MRgFUS Thalamotomy Using a Diffusion Weighted Steady State MRI Sequence in an In-vivo Porcine Model

Juan Camilo Plata¹, Sam Fielden², Bragi Sveinsson³, Brian Hargreaves⁴, and Craig Meyer²

¹Bioengineering, Stanford University, Las Vegas, NV, United States, ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ³Electrical Engineering, Stanford University, Palo Alto, CA, United States, ⁴Stanford University, Palo Alto, CA, United States

Early detection of thermal lesions generated using MR-guided focused ultrasound systems is critical for treatment feedback. Irreversible changes in the apparent diffusion coefficient (ADC) have been previously shown to be an early indicator for loss of viability in the prostate. Due to poor image quality using standard diffusion weighted imaging strategies inside the focused ultrasound system, radiologists rely on T2-weighted fast spin echoes (FSE) for lesion detection. T2-weighted changes due to lesion formation develop more slowly than ADC changes. We propose using a diffusion-weighted steady state sequence for early detection of thermal lesions inside the focused ultrasound system.

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