Intracellular volume fraction estimation in vivo in single and crossing fibre regions
Sjoerd B Vos1,2, Andrew Melbourne1, John S Duncan2,3, and Sebastien Ourselin1
1Translational Imaging Group, University College London, London, United Kingdom, 2MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, 3Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom
Intracellular volume fraction (ICVF) is a
valuable biomarker of neurological disease. As one of two factors in g-ratio
estimates it could potentially reveal axonal function from structural MRI
measurements. Reliable ICVF estimation is critical for both purposes. With various
diffusion models in existence for ICVF estimation, we compared the obtained
ICVF values and their reproducibility in voxels with 1, 2, and 3 fibre
populations between three diffusion modelling approaches. Absolute ICVF values
vary significantly between models as well as between voxels with different
fibre complexity.
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