Marco Reisert1, Elias Kellner1, Bibek Dhital1, Jürgen Hennig1, and Valerij G. Kiselev1
Diffusion-sensitized MRI probes the cellular structure of the human brain, but the primary microstructural information gets lost in averaging over higher-level, mesoscopic tissue organization such as different orientations of neuronal fibers. While such averaging is inevitable due to the limited imaging resolution, we propose a method for disentangling the microscopic cell properties from the effects of mesoscopic structure. The proposed method finds detectable parameters of a given microstructural model and calculates them within seconds, which makes it suitable for a broad range of applications.
