Abstract #1721

Is the local functional connectivity anisotropy (LFCA) in white matter caused by neuro-electric activity? An examination of potential confounds for orientation-dependent LFCA in fMRI

Michael J. Tobia¹, David Gallagher¹, Rahul Dewal¹, Sebastien Rupprecht¹, Prasanna Karunanayaka¹, and Qing X. Yang¹

¹Radiology, Penn State Hershey, Hershey, PA, United States

Phantom experiments showed that fluctuating electric current is sufficient to generate local functional connectivity anisotropy (LFCA), and that effects of motion, such as Lorentz forces, cannot explain the alignment of eigenvectors through neighboring voxels or B0 orientation-dependence. In conclusion, anisotropic correlations of fMRI time series may arise from an alternative non-BOLD contrast mechanism, potentially related to an electric current effect on B0.

This abstract and the presentation materials are available to members only; a login is required.

Join Here