Maria Guidi1, Christopher J. Steele1, Laurentius Huber2, Leonie Lampe1, Viola Rjosk1, Pierre-Louis Bazin1, and Harald E. Möller1
Motor tasks have been extensively studied with BOLD fMRI. The way the BOLD response scales with task intensity level might come from an increased metabolic activity as well as an increased CBF and CBV. In this study, we aimed at disentangling such contributions combining a gas manipulation session with a pinch-task with simultaneous recording of force values. This way, the Davis model for calibration of fMRI could be applied and the oxygen metabolism changes estimated at every timestep. BOLD signal changes, VASO signal changes, and CMRO2 changes were shown to weakly scale with the intensity of the pinch-force task.
