Abstract #1510

A Study on CrCEST Mapping in Human Brain at 7T MRI

Anup Singh^1,2, Mohammad Haris³, Kejia Cai⁴, Hari Hariharan⁵, and Ravinder Reddy⁵

¹Centre for Biomedical Enineering, Indian Institute of Technology Delhi, New Delhi, India, ²Biomedical Engineering, AIIMS Delhi, New Delhi, India, ³Research Branch, Sidra Medical and Research Center, Doha, Qatar, ⁴Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁵Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Creatine(Cr) is a significant brain metabolite and its alterations has been reported in various disease conditions. In this study, chemical-exchange-saturation-transfer (CEST) MRI of Creatine(CrCEST) was performed in human brain at 7T MRI scanner. Numerical simulations were also carried out for evaluating contributions from other brain metabolites to CrCEST and a method to reduce this contamination was proposed based upon simulated data observations. Using, conventional CESTasy method, CrCEST has ~50% contribution from Cr. Using proposed subtraction based approach it is feasible to reduce contaminations from other metabolites/molecules and hence making CrCEST more specific to Cr.

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