Abstract #1509

Monitoring therapeutic response on medullary thyroid carcinoma in chemotherapy by amide proton transfer (APT) imaging in an orthotopic mouse model

Keisuke Ishimatsu¹, Karine Pozo², Shanrong Zhang¹, Koji Sagiyama¹, Osamu Togao¹, James Bibb³, and Masaya Takahashi¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Psychiatry / Harold C. Simmons Comprehensive Cancer Center / Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States

The objective is to investigate whether amide proton transfer (APT) imaging is useful for evaluation of anticancer treatment responses in chemotherapy. We compared the temporal changes of APT signal with the different treatment strategies using two new drugs, administered individually or in combination, in a mouse model of medullary thyroid carcinoma.

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