Abstract #1472

Contrast Enhanced MRI Reveals Perplexing T2 effect of Aggregate Forming Compounds In the Murine Placenta

Marina Lysenko¹, Noam Ben-Eliezer¹, Inbal E Biton², Joel R Garbow³, and Michal Neeman¹

¹Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, ²Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel, ³Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, United States

The murine placenta is a complex organ, consisting of different cell compartments that greatly influence its blood-flow pattern. Dynamic contrast enhanced (DCE) MRI of murine placental perfusion has been reported previously using both low and high MW contrast media. In this study, we used high-MW, albumin-based macromolecular contrast agent that does not cross the placental barrier, but, instead, forms contrast-based aggregates that accumulate in the maternal vasculature simultaneously with active contrast internalization by trophoblast cells in the labyrinth .To interpret the observed data, we suggest a novel model for describing feto-maternal processing and aggregate formation of labeled albumin in placental DCE-MRI experiments.

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