Hyperemic Blood-Oxygen Level Dependent MRI of the foot for identifying perfusion defects in those with peripheral arterial disease
Tomoki Fujii1, Krishna R. Singh2, Bill Bordeau3, Joao A. Lima1, and Bharath Ambale-Venkatesh1
1Johns Hopkins University, Baltimore, MD, United States, 2Prairie Vascular Institute, Springfield, IL, United States, 3Zimmer Biomet Biologics, Warsaw, IN, United States
Peripheral artery disease is a major public health concern particularly among the elderly. Although measures such as ankle-brachial index and segmental pressures have been used to characterize disease severity, MRI techniques allow us to assess subclinical vascular function and morphology and may help improve our understanding of vascular adaptations. In a small pilot study, we test whether hyperemia-induced BOLD oxygenation changes are a viable measure of tissue oxygenation in the foot and if they represent the reduced oxygenation seen in PAD.
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