Abstract #1441

Dynamic Changes of Amide Proton Transfer (APT) and Multi-parametric MRI Signals in Transient Focal Ischemia in Rats

Dong-Hoon Lee¹, Xuna Zhao¹, Hye-Young Heo¹, Yi Zhang¹, Shanshan Jiang¹, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

APT MRI is a novel imaging technique to provide in vivo image contrasts related with the changes of endogenous mobile amide proton concentration and/or tissue pH. In this abstract, based on the quantified APT signals and multi-parametric MR images, we attempted to evaluate signal changes in transient focal ischemia in rat models. Our results clearly showed that the APT imaging can be a useful technique to predict the ischemia reperfusion status, and to provide the quantitative results more accurately.

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