Abstract #1440

A marker for hyperacute ischemic stroke at ultra-low magnetic field

Mathieu Sarracanie^1,2,3, Fanny Herisson⁴, Najat Salameh^1,2,3, Cenk Ayata⁴, and Matthew Rosen^1,2,3

¹MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Physics, Harvard University, Cambridge, MA, United States, ⁴Department of Radiology, MGH/Neurovascular Research Lab, Boston, MA, United States

Ischemic stroke treatment with a thrombolytic agent given in the hyperacute phase can greatly impact the outcome for stroke patients, however stroke status monitoring with CT and MRI is generally only possible once patients are admitted to a hospital. Here, we demonstrate T₁ contrast at ultra-low magnetic field strength in a rat model of stroke, with subtle changes noticeable as early as t=20min, and more clearly at t=3h and t=24h following stroke onset. We believe that the use of portable, ultra-low field MRI scanners as an early-detection methodology could have great impact on the treatment and monitoring of ischemic stroke.

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