Abstract #1269

Intrinsic Functional Connectivities of “Where” Visual Network in Patients with Mild Cognitive Impairment

Yanjia Deng¹, Lin Shi^2,3, Defeng Wang^1,4,5, and ADNI Alzheimer’s Disease Neuroimaging Initiative⁶

¹Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China, People's Republic of, ²Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, People's Republic of, ³Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, China, People's Republic of, ⁴Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China, People's Republic of, ⁵Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China, People's Republic of, ⁶Los Angeles, CA, United States

In order to extend the knowledge on the impaired pattern of “where” visual perception in mild cognitive impairment (MCI) patients, we investigated the connectivity of the “where” visual networks in terms of intrinsic interaction in early and late MCI patients. Resting-state functional MRI data of late MCI, early MCI and matched healthy controls from Alzheimer’s Disease Neuroimaging Initiative dataset were analyzed to investigate the alterations of interregional connections of “where” visual networks. Significant increased interregional connectivties in late MCI patients were found, which may extend the current knowledge on the pattern of visual perceptual impairment in MCI patients.

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