Abstract #1268

The joint effects of APOE genotype and age on functional network in non-demented old adults

Liang Gong¹, Hao Su¹, Cancan He¹, Qing Ye¹, Feng Bai¹, Chunming Xie¹, and Zhijun Zhang¹

¹Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, People's Republic of

A cross-sectional resting-state functional magnetic resonance imaging study was conducted with 84 aMCI subjects (including 9 APOE ε2, 45 ε3, 28 ε4 carriers) and well-matched 124 cognitively normal (CN) healthy elders (including 35 APOE ε2, 43 ε3, 46 ε4 carriers). The finding revealed that the ε2 carriers and ε4 carriers showed convergent effects on right AFC but divergent effects on left AFC network when CN compared to aMCI patients. Interactive effects of APOE genotypes and age on AFC network further revealed neural basis of ten years earlier on the age of onset in aMCI patients. Further, mediation analysis suggested that connectivity strength mediated the effects of APOE genotypes and age on the cognitive function in aMCI patients.

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