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Abstract #1221

1H NMR-based Metabolomics study of saliva samples in Patients with Parkinson’s disease

Sadhana Kumari1, Senthil S Kumaran1, Vinay Goyal2, Madhuri Behari2, S N Dwivedi3, Achal Srivastava2, and Naranamangalam R Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, 3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

NMR techniques play a major role in understanding the metabolic changes associated with neurological disorders. We used 1H NMR spectra at 700 MHz for identification of biomarkers in PD from saliva samples. The data were processed using MestReNova software (version 10.0) and PLS-DA multivariate analysis using MetaboAnalyst (version 3.0) software. We observed significantly elevated level of butyrate, glycine, phenyl alanine, tyrosine and decreased level of lactate, which may be attributed to poor intestinal absorption in PD patients.

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Abstract