Abstract #1220

Periventricular Longitudinal Neural Tracts Are Implicated in Postural Instability Gait Disorder

Shawn Tan¹, Nicole Keong², Ady Thien², HuiHua Li¹, Helmut Rumpel¹, EK Tan², and Ling Chan¹

¹Singapore General Hospital, Singapore, Singapore, ²National Neuroscience Institute, Singapore, Singapore

Postural instability gait disorder (PIGD) is associated with predominant gait dysfunction compared to typical tremor dominant Parkinson’s disease (PD). We evaluated the periventricular longitudinal neural tracts in PIGD using DTI compared to PD and controls, and examined their clinical correlates. We showed for the first time that these neural tracts are more affected in PIGD than PD or HC, and their DTI measures correlate with clinical gait severity. It has been postulated that disconnection of motor networks served by these tracts linking brain regions involved in executive function and visuoperception with those involved in gait control leads to gait decline.

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