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Abstract #1107

Dynamic 31P MRSI with spiral readout for quantification of mitochondrial capacity in muscles of the calf during plantar flexion exercise at 7T

Ladislav Valkovič1,2,3,4, Marek Chmelík1,2, Martin Meyerspeer1,5, Borjan Gagoski6, Martin Krššák1,2,7, Christopher T Rodgers4, Ivan Frollo3, Ovidiu C Andronesi8, Siegfried Trattnig1,2,9, and Wolfgang Bogner1,2

1High-field MR Centre, Medical University of Vienna, Vienna, Austria, 2Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 4Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 5Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 6Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 7Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 8Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 9Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Typically, only rough localization by the sensitive volume of the surface coil is used for dynamic 31P-MRS. However, such localization often mixes signals from several muscle groups. Available single-muscle localization techniques (e.g., semi-LASER or DRESS) provide only limited coverage and current 31P-MRSI techniques suffer from slow acquisition. To overcome the low temporal resolution of the standard 31P-MRSI, caused by slow Cartesian readout, we have developed, and tested in healthy subjects at 7T, a 31P-MRSI sequence using spiral readout trajectory. This sequence enables spatially resolved quantification of mitochondrial capacity in several investigated muscles (e.g., GM, GL and SOL) simultaneously at 7T.

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