Bertrand Pouymayou1, Tania Buehler1, Roland Kreis1, and Chris Boesch1
31P-MR spectroscopy inversion
transfer (IT) is increasingly investigated as a complementary method to
study ATP-synthesis and creatine kinase in vivo. Three aspects of the IT
experiment are studied here, in a test-retest design (12 volunteers,
resting vastus muscle): the ability to produce an efficient half band
inversion in vivo with a short asymmetric adiabatic pulse, the
repeatability of the kinetic parameters
estimation at 3T and the impact of two different fitting
strategies (individual spectrum vs. two-dimensional fitting). As a result,
k[Pi>γ-ATP] can be reliably estimated within cohorts while
k[PCr>γ-ATP] is accurate enough to be distinguished between individuals.
