Abstract #1104

Rapid and Simultaneous Measurements for Reaction Kinetics and Metabolite Pool Size Ratios using 31P Magnetization Saturation Transfer Spectroscopy

Sang-Young Kim^1,2, Wei Chen³, Dost Ongur², and Fei Du^1,2

¹McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, United States, ²Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

We demonstrates a novel strategy to simultaneously measure metabolites pool sizes and kinetic constants of CK/ATPase reactions using 31P-MST spectroscopy. Our method enables the corrections for T₁ relaxation time and chemical exchanges effects due to short TR. The most important advantage of our proposed method is the reduction of TR for complete measurements of both metabolites ratios and reaction kinetics with high sensitivity. This can facilitate future applications requiring high temporal and/or spatial resolution.

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