Abstract #0948

Effective Connectivity Measured with Layer-Dependent Resting-State Blood Volume fMRI in Humans

Laurentius Huber¹, Daniel A Handwerker¹, Javier Gonzalez-Castillo¹, David C Jangraw¹, Maria Guidi², Dimo Ivanov³, Benedikt A Poser³, Jozien Goense⁴, and Peter A Bandettini¹

¹Section of Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, United States, ²Human Cognitive and Brain Sciences, Max Planck Institute, Leipzig, Germany, ³MBIC, Maastricht University, Maastricht, Netherlands, ⁴Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom

Measurements of layer-dependent cortical activity provide insight on how feedforward/feedback functional connectivity affects a given cortical area. Here, we simultaneously measure layer-dependent changes in resting-state BOLD and CBV with VASO. We demonstrate that the superior specificity of CBV fMRI reveals layer-dependent resting-state activity better than GE-BOLD fMRI and gives indications of effective connectivity in the human sensory-motor system. In particular, superficial and deeper layers in M1 show different connectivity patterns than those associated with the middle layer, likely driven by input from S1. Our data show that the middle layer in M1 correlates with contralateral M1, while it anti-correlates with contralateral S1.

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