Abstract #0925

Post-mortem inference of the inner connectivity of the human hippocampus using ultra-high field diffusion MRI at 11.7T

Justine Beaujoin^1,2,3, Fawzi Boumezbeur^1,2,3, Jérémy Bernard^1,2,3, Markus Axer⁴, Jean-François Mangin^2,3,5,6, and Cyril Poupon^1,2,3,6

¹CEA NeuroSpin / UNIRS, Gif-sur-Yvette, France, ²Université Paris-Saclay, Orsay, France, ³FLI / Noeud Paris-Sud, Orsay, France, ⁴Forschungszentrum Jülich, INM1, Jülich, Germany, ⁵CEA NeuroSpin / UNATI, Gif-sur-Yvette, France, ⁶http://cati-neuroimaging.com/, Gif-sur-Yvette, France

In this work, we demonstrate that post-mortem ultra-high field (11.7T) / ultra-high gradients (760mT/m) diffusion-weighted MRI allows to finely map the inner connectivity of the human hippocampus and we show that the polysynaptic intra-hippocampal pathway can be accurately reconstructed using fiber tractography techniques at very high spatial/angular resolutions.

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