Kurt Schilling1, Vaibhav Janve1, Yurui Gao1, Iwona Stepniewska1, Bennett Landman1, and Adam Anderson1
It
has been reported that diffusion tractography has a tendency for streamlines to
terminate preferentially on gyral crowns rather than on sulcal walls or fundi.
Rather than anatomical reality, it has been suggested that this is a bias
associated with tractography. To better understand this issue, we compare
histology to diffusion MRI of the same specimen. We measure the trajectories
and density of axons crossing the gray matter/white matter boundary and compare
to diffusion tensor measures and deterministic tractography. The results of
this study lead to a better understanding of gyral anatomy and potential
limitations of fiber tractography.
