Abstract #0898

In-vivo evaluation of hypometabolism associated with muscular dystrophy using Creatine CEST MRI

Rong-Wen Tain^1,2, Ahlke Heydemann^3,4, Alessandro Scotti^1,5,6, Weiguo Li^7,8, Xiaohong Joe Zhou^1,5,6,9, and Kejia Cai^1,5,6

¹Radiology,College of Medicine, University of Illinois, Chicago, IL, United States, ²3T Research Program, Center for MR Research, College of Medicine, University of Illinois, Chicago, IL, United States, ³Physiology & Biophysics,College of Medicine, University of Illinois, Chicago, IL, United States, ⁴Center for Cardiovascular Research, College of Medicine, University of Illinois, Chicago, IL, United States, ⁵3T Research Program, Center for MR Research, University of Illinois, Chicago, IL, United States, ⁶Bioengineering, University of Illinois, Chicago, IL, United States, ⁷Research Resource Center, University of Illinois, Chicago, IL, United States, ⁸Radiology, Northwestern University, Chicago, IL, United States, ⁹Neurosurgery, University of Illinois, Chicago, IL, United States

This study aims to measure hypometabolism in the muscle due to muscular dystrophy using creatine CEST MRI. We acquired images of the lower limbs from the diseased and wild-type mice. Differences in the Z-spectrum and creatine CEST contrast map were seen between fibrotic and normal muscles. This suggested that CrCEST MRI may serve as a sensitive imaging biomarker for metabolic changes associated with muscular dystrophy.

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