Abstract #0897

Propionate as a Probe For Myocardial Metabolism – A Biochemical and Hyperpolarized MR Study

Mukundan Ragavan¹, Xiaorong Fu², Shawn C Burgess², and Matthew E Merritt¹

¹Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States, ²University of Texas Southwestern Medical Center, Dallas, TX, United States

In this study, the utility of sodium propionate for accentuating changes in cardiac metabolism is evaluated. The study is performed using a murine model of cardiac hypertrophy and employs hyperpolarized magnetic resonance spectroscopy, mass spectrometry and a biochemical assay to determine the cardiac redox state. Results show propionate modulates cardiac metabolism across a range of different concentrations.

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