Abstract #0822

Preclinical Study of MRgFUS Ablation of the Lumbar Medial Branch Nerve: Functional Outcomes and Histology

Elena Kaye¹, Sebastien Monette², Majid Maybody³, Stephen B Solomon³, and Amitabh Gulati⁴

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Comparative Pathology, Sloan Kettering Institute, New York, NY, United States, ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Anesthesiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

The main goals of this preclinical study were to determine whether direct MRgFUS ablation of the lumbar MB nerve leads to functional changes and to study the extent of the thermal damage to the targeted and adjacent tissues, including neurologic structures. We found that direct FUS ablation of the lumbar MBN achieves thermal necrosis of the targeted nerve with minimal thermal damage of the adjacent bone and muscle tissue. The extent of the cellular changes in bone is limited to a few millimeters with no changes in the spinal cord, confirming the protective effects of spine bone rapidly attenuating the ultrasound. No functional changes were observed.

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