Abstract #0814

IN VIVO HYPERCEST DETECTION OF CUCURBIT[6]URIL IN RAT ABDOMEN

Francis Hane¹, Tao Li¹, Peter Smylie¹, and Mitchell S Albert¹

¹Lakehead University, Thunder Bay, ON, Canada

We used the MRI HyperCEST technique to detect the presence of the xenon encapsulating cage molecule cucurbit[6]uril (CB6) in the abdomen of a rat. We believe that this is the first in vivo demonstration of a xenon based biosensor. We were able to observe a HyperCEST signal depletion of 53% within the intraperitoneal space of the rat. Our results demonstrate the feasibility of HyperCEST biosensors to move from in vitro to in vivo studies.

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