Resting state and stimulus evoked fMRI in awake, head-posted and habituated rats.
Pei-Ching Chang 1, Daniele Procissi2, Maria Virginia Centeno1, and Vania Apkarian1
1Physiology, Northwestern University, Chicago, IL, United States, 2Radiology, Northwestern University, Chicago, IL, United States
fMRI in rodents is a major tool for basic neuroscience research. It allows investigation of brain networks in different animal models of disease and injury using translational methods with clinical relevance. In many instances it is essential to image animals in an awake condition (i.e. without anesthesia). While several have shown it is possible to image animals in the awake condition they nearly all require initial anesthesia and forced restraint. In this study we describe a strategy to image rats trained to be "comfortably" restrained and head posted and show how it is possible to enhance the performance of the fMRI experiments.
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