Celia M. Dong1,2, Patrick P. Gao1,2, Leon C. Ho1,2, Alex T.L. Leong1,2, Russell W. Chan1,2, Xunda Wang1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of
Anesthesia is needed in many neuroscience studies but its effect on
brain network response properties has not been fully understood. In particular,
how it modulates crossmodal sensory responses remains largely unknown. This study
investigated the brain responses to auditory stimulation at different
isoflurane levels using large-view BOLD fMRI. Robust responses to multiple pure
tone sound stimuli were detected in the bilateral visual cortex at 2.5%
isoflurane but not at 1.0% isoflurane level. These results revealed the broad
and profound modulation effects of anesthesia on brain crossmodal response
properties during external sensory stimulation.
