Abstract #0732

Mapping longitudinal white matter changes in extremely preterm born infants

Eliza Orasanu¹, Andrew Melbourne¹, Marc Modat¹, Marco Lorenzi¹, Herve Lombaert², Zach Eaton-Rosen¹, Nicola Robertson³, Giles Kendall⁴, Neil Marlow⁵, and Sebastien Ourselin¹

¹Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom, ²INRIA, Palaiseau, France, ³Academic Neonatology, Institute for Women's Health, University College London, London, United Kingdom, ⁴Academic Neonatology, Institute for Women's Health, University College Hospital, London, United Kingdom, ⁵Institute for Women's Health, University College London, London, United Kingdom

During the preterm period, the brain undergoes changes in volume, structure and cortical folding, which can be connected with cognitive abilities in preterm born infants. Diffusion MRI allows us to investigate microstructural changes during this period. In this study we registered the longitudinal diffusion tensor images of six extremely preterm born infants and looked at white matter changes. The corpus callosum and internal capsule exhibits the most microstructural changes during this crucial period and we hypothesis that this can affect the neurodevelopment in these infants.

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