Abstract #0731

Altered Cortical and Subcortical Structures and Structural Connectivity in Perinatally HIV-infected Children

Santosh Kumar Yadav¹, Rakesh Kumar Gupta², Ravindra Kumar Garg³, Vimala Venkatesh⁴, Ena Wang¹, Francesco M Marincola¹, and Mohammad Haris¹

¹Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ²Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, ³Department of Neurology, King George Medical University, Lucknow, India, ⁴Department of Microbiology, King George Medical University, Lucknow, India

Cortical thickness, subcortical volumes and structural brain connectivity changes in HIV-seropositive children were evaluated in comparison to HIV-seronegative children. HIV-seropositive children showed altered cortical thicknesses, subcortical volumes and structural connectivity compared to those of HIV-seronegative children. In addition, changes in cortical and subcortical structures were significantly correlated with CD4+ counts and neuropsychological scores in HIV-seropositive children. We suggest that neuronal injury due to HIV-infection and inflammation might be possible reasons for the altered cortical thickness, subcortical volumes and connectivity in these patients.

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