Relationship between Cerebrovascular Reserve and Brain Temperature following Acetazolamide Challenge in Patients with Chronic Steno-Occlusive Disease
Seena Dehkharghani1, Candace C. Fleischer2, Deqiang Qiu1, Sang-Eon Park2, Junjie Wu1, and Fadi Nahab3
1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States, 3Neurology, Emory University, Atlanta, GA, United States
Methods for
characterizing misery perfusion to
predict stroke are largely limited to positron emission tomography, which
suffers from high radiation exposure. Magnetic resonance imaging (MRI) and
spectroscopy (MRS) offer non-invasive alternatives to explore cerebral
hemodynamics and brain temperature regulation, a poorly understood physiologic
variable at the intersection of perfusion and metabolism. We detail the first
reported use of MRI/MRS to relate cerebrovascular reserve with temperature in
patients following acetazolamide challenge, observing significant correlation
between temperature changes and cerebrovascular reserve. These findings will be
used to inform future MRI studies of perfusion and brain temperature among
patients with chronic steno-occlusive disease.
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