Perivascular spaces (PVS) have been described as
non-enhancing structures with a fluid signal. In this study, we confirmed that
PVS signals are enhanced in images obtained 4 hours after intravenous
administration of gadolinium based contrast agent (GBCA) in human subjects
without renal insufficiency. Contrast enhancement of CSF was also observed. It
is possible that GBCA in the blood vessels might have permeated into the CSF
space and PVS. This could be the route by which GBCA is distributed to brain
parenchyma through the glymphatic system
in subjects with a normal blood brain barrier.
