Gregor Jost1, Diana Lenhard2, Jessica Lohrke1, Thomas Frenzel1, and Hubertus Pietsch1
1MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, 2Institute of Vegetative Physiology, Charité, Berlin, Germany
Recent publications reported increased T1-weighted (T1w) signal
intensities (SI) in the dentate nucleus and globus pallidus after repeated
administrations of gadolinium based contrast agents (GBCAs). In the present
animal study the T1w SI of three linear and two macrocyclic GBCAs were
systematically evaluated after ten administrations each with a dose of 2.5
mmol/kg. Increased cerebellar nuclei to pons SI ratios were found after
administration of linear GBCAs (significantly increased for gadodiamide and gadobenate
dimeglumine, and non-significantly increased for gadopentetate dimeglumine). In
contrast no elevated SI ratios were observed after administration of the macrocyclic
GBCAs gadobutrol and gadoterate meglumine or saline.
