Abstract #0457

Preliminary Results: Cardiac Cine “Watermark” MRI provides both Anatomical Function via Magnitude Cine and 2D Myocardial Strain via Spatially Modulated Phase

Ronald J Beyers¹, Davis M Vigneault², Dean Schwartz³, Nouha Salibi^1,4, David A Bluemke², and Thomas Denney¹

¹MRI Research Center, Auburn University, Auburn University, AL, United States, ²Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ³Anatomy, Physiology and Pharmacology, Auburn University, Auburn University, AL, United States, ⁴MR R&D, Siemens Healthcare, Malvern, PA, United States

We developed a Cine Watermark (CWM) cine sequence that produces normal cine magnitude images, plus a grid pattern of tags added only in the phase for quantitative cine strain, while requiring no extra operator effort. Using spatial cosine modulation combined with k-space sum/differencing produced separate normal magnitude cine and unique phase-only grid-tags for strain calculation. In vivo rat and human scans demonstrated good magnitude cine and phase-only quantified displacement. Calculated by Farneback optical flow algorithm, the peak principle strain, averaged around the LV for rat = -16.5±2.4 % and human = -17.8±6.2 % (mean±StdDev).

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