Abstract #0280

Real-time fMRI Neurofeedback with Simultaneous EEG in Combat-related PTSD: Frontal EEG Asymmetry Variations as Measure of Treatment Response

Vadim Zotev¹, Raquel Phillips¹, Masaya Misaki¹, Chung Ki Wong¹, Brent Wurfel¹, Matthew Meyer^1,2, Frank Krueger^1,3, Matthew Feldner^1,4, and Jerzy Bodurka^1,5

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, ³Neuroscience Dept., George Mason University, Fairfax, VA, United States, ⁴Dept. of Psychological Science, University of Arkansas, Fayetteville, AR, United States, ⁵College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have performed a study of emotion regulation training in veterans with combat-related PTSD using real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG. Fifteen PTSD patients learned to upregulate their left amygdala activity using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. Individual session-to-session variations in frontal EEG asymmetry (FEA) changes during the rtfMRI-nf task significantly correlated with variations in PTSD severity (CAPS) and co-morbid depression severity (HDRS). These results suggest that variations in task-specific FEA changes during rtfMRI-nf training provide a sensitive measure of individual response to treatment in PTSD patients.

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