Abstract #0279

A serial microcompartment-specific T2* relaxation study of white matter lesions in multiple sclerosis at 7T

Xiaozhen Li^1,2, Peter van Gelderen², Pascal Sati³, Jacco de Zwart², Daniel Reich³, and Jeff Duyn²

¹Dept. NVS, Karolinska Institutet, Stockholm, Sweden, ²Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States, ³Translational Neuroradiology Unit, NINDS, National Institutes of Health, Bethesda, MD, United States

Multiple sclerosis (MS) is a chronic demyelinating disease characterized by focal lesions. Recent studies suggest the possibility of obtaining cellular microcompartment-specific information from three-component fitting of the T₂^* relaxation decay curve, allowing determination of the relative fractions of myelin water, axonal water and interstitial water. The microcompartment-specific T₂^* relaxation values of initially enhancing lesions were followed serially on 7T at approximately 3, 6, and 12 months. The changes over time that we observed in enhancing lesions are consistent with the presence of ongoing remyelination. This may lead to a better understanding of, and prognostic ability for, this complex disease.

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