1Department of Radiobiology and Medical Engineering, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Global Institution for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan, 3Research Laboratories, Hamburg, Germany, 4Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 5Graduate School of Health Sciences, Sapporo, Japan, 6Hokkaido University Hospital, Sapporo, Japan