Abstract #0264

Orientation anisotropy of quantitative rotating and laboratory frame relaxation parameters in articular cartilage

Jari Rautiainen¹, Lassi Rieppo^2,3, Simo Saarakkala^2,3,4, and Mikko Johannes Nissi^1,5

¹Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, ²Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ³Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, ⁴Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, ⁵Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

Classical ($$$T_1$$$, $$$T_2$$$) and several rotating frame quantitative MR parameters have been used for evaluation of composition and structure of articular cartilage, and demonstrated to have variable sensitivity to tissue orientation. The orientation dependence of $$$T_1$$$, $$$T_2$$$, $$$T_2^*$$$, CW-$$$T_{1\rho}$$$ with four spin-lock amplitudes, adiabatic $$$T_{1\rho}$$$ with three different pulse modulations, adiabatic $$$T_{2\rho}$$$ and $$$T_{\rm RAFF}$$$ relaxation times were further investigated at 9.4T at different orientations of articular cartilage relative to B0 and compared with polarized light microscopy of the same tissue. $$$T_1$$$, adiabatic $$$T_{1\rho}$$$ with HS1-pulse and CW-$$$T_{1\rho}$$$ at 2 kHz spin-lock demonstrated the least orientation dependence.

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