Abstract #0220

BOLD Hemodynamic alteration in Brain Tumors

Lalit Gupta¹, Rakesh K Gupta², Prativa Sahoo¹, Pradeep K Gupta², Rana Patir³, Sandeep Vaishya³, Indrajit Saha⁴, and Walter Backes⁵

¹Philips India Ltd., Bangalore, India, ²Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, ³Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India, ⁴Philips India Ltd., Gurgaon, India, ⁵Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands

The objective of the study is to determine the temporal delay in cerebral hemodynamic flow in brain tumors relative to normal brain tissue using rsfMRI and compare this with DCE derived cerebral blood volume(CBV) maps. Time series from all the voxels were cross-correlated with the mean time series from the normal hemisphere. The time point with maximum correlation was used to generate temporal shift map(TSM) for each voxel. We observed early hemodynamic changes in high grade glioma and found significant difference in the mean TSM ratio between Glioblastoma(GBM) and low grade tumors. TSM also appeared similar to rCBV perfusion maps.

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