Abstract #0219

Mapping resting state networks in epilepsy with Arterial Spin Labeling connectivity analysis

Ilaria Boscolo Galazzo^1,2, Silvia Francesca Storti³, Anna Barnes¹, Enrico De Vita⁴, Francesca Benedetta Pizzini², John Duncan⁵, Ashley Groves¹, Gloria Menegaz³, and Francesco Fraioli¹

¹Institute of Nuclear Medicine, University College London, London, United Kingdom, ²Department of Neuroradiology, University Hospital Verona, Verona, Italy, ³Department of Computer Science, University of Verona, Verona, Italy, ⁴Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ⁵Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom

In this study, we propose the assessment of resting-state brain networks (RSNs) using Arterial Spin Labeling perfusion MRI as an alternative to the gold-standard sequence represented by the Blood-oxygenation-level-dependent (BOLD) contrast. RSNs have been derived by means of independent component analysis (ICA) and spatially compared to literature networks. In addition, functional connectivity changes in epileptic patients have been quantified in comparison to healthy controls. The results demonstrated ASL suitability in identifying RSNs, with a strong agreement with BOLD, and in detecting functional alterations in pathological conditions.

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