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Abstract #4919

Ultra-high Resolution In-vivo 7.0T Structural Imaging of the Human Endfolial Pathway

Mansi Parekh 1 , Ryan Purcell 2 , Sherveen Parivash 1 , Brian Rutt 1 , and Michael Zeineh 1

1 Radiology, Stanford University, Stanford, CALIFORNIA, United States, 2 Neuroscience, University College London, London, United Kingdom

The hippocampal hilus may have unique neuroanatomy in humans compared to monkeys and rodents, with CA3h greatly enlarged and a unique white-matter pathway called the endfolial pathway present. In this stud,y we used newly developed 7.0T whole brain imaging achieving 0.4mm isotropic images to study in vivo the anatomy of the hippocampal hilus. We validate these in vivo finding with 0.1mm isotropic excised specimen images as well as histologically using a myelin stain. The endfolial pathway is a central pathway in the hippocampus, possibly unique to humans, and poorly described. However, our methodology will allow for its study and understanding its function.

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