Abstract #4918
Ultra high field MR spectroscopy of the striatum in the human brain: On the relation between striatal metabolites and performance on a search step task
Joost Haarsma 1,2 , Jannie P Wijnen 1 , Kathy N Thakkar 2 , Dennis WJ Klomp 1 , and Bas Neggers 2
1
Radiology, University Medical Centre
Utrecht, Utrecht, Utrecht, Netherlands,
2
Psychiatry,
University Medical Centre Utrecht, Utrecht, Utrecht,
Netherlands
Response inhibition has been investigated using the
oculomotor search-step task. Research into the neural
substrates involved in response selection tasks (like
the one used in this study) has pointed towards a
crucial role for the basal ganglia, which influence
action largely via GABAergic neurotransmission. We
therefore hypothesized a relation between GABA levels
(measured using ultra high field MR-spectroscopy) in the
striatum, the input node of the basal ganglia, and
performance on the search step-task in healthy
participants. At highest MR sensitivity, no significant
correlations between GABA levels and performance on the
search-step task were found in this study.
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