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Abstract #4793

Metabolism of hyperperfused tissue after stroke reperfusion therapy.

Andrew Bivard 1 , Venkatesh Krishnamurthy 2 , and Mark Parsons 2

1 Medicine, University of Melbourne, Melbourne, Vic, Australia, 2 University of Newcastle, NSW, Australia

Hyperperfusion on arterial spin labeling (ASL) has been associated with improved clinical outcome. We sort to assess the metabolic profile of patients recovering from ischemic stroke following successful reperfusion and penumbra salvage. Magnetic resonance spectroscopy was performed in 60 patients 24 hours after symptom onset with voxels were placed in the reperfused tissue that did not infarct on diffusion imaging and exactly contralateral. Hyperperfusion and increased glutamate on MRS in recently reperfused tissue was significantly related to improved patient outcome on the modified Rankin disability scale (p<0.001). Increased glutamate and was a marker of significantly better patient outcome following stroke.

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