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Abstract #4792

3D high resolution MPRAGE helps identify intraplaque hemorrhage in patients with intracranial atherosclerotic diseases

Lei Zhang 1,2 , Qi Yang 3 , Xin Liu 1,2 , and Yiu Cho Chung 1,2

1 Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, Guangzhou, China, 2 Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, Guangzhou, China, 3 Radiology Department, Xuanwu Hosptial, Capital Medical University, Beijing, Beijing, China

Atherothrombotic intracranial disease is a major cause of cerebral ischemia. Lesion enhancement may be detected using high resolution T1 weighted imaging. MPRAGE are commonly used to detect thrombus in carotid plaques and other vascular beds. This study proposes the combined use of T1 weighted imaging and MPRAGE to help identify intraplaque hemorrhage. The protocol was applied in 10 patients diagnosed with intracranial artery stenosis. It was found that the lesions may or may not enhance post-contrast, and contrast enhancement of the lesion may not have associated hyperenhancement in MPRAGE.

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