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Abstract #4785

Remote Effect of Acute Ischemic Stroke Revealed by Microstructure and Fiber Density Analysis

Dai Shan 1 , Chunxiang Jiang 1 , Xiaojing Long 1 , Yanjun Diao 1 , and Lijuan Zhang* 1

1 Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, Guangdong, China

We explored the remote effect of ischemic stroke by comparing the microstructural indices and fiber density in cerebral peduncles (CP) in 14 subjects diagnosed with single and unilateral ischemic stroke remote to the CP. Fiber density was dramatically decreased in the CP ipsilateral to the lesion while mean diffusivity and fractional anisotropy did not manifest significant difference between the bilateral CPs. Fiber density may serve as a sensitive index identifying remote white matter damage in acute ischemic stroke.

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