Abstract #4784
Effects of pre-reperfusion NBO administration in experimental ischemic stroke
Yash Vardhan Tiwari 1 , Yuhao Sun 1 , Fang Du 1 , Qiang Shen 1 , and Timothy Q Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center San Antonio, San Antonio,
Texas, United States
Normobaric hyperoxia (NBO) has shown to improve and
worsen stroke outcomes in ischemic stroke. The positive
outcome of NBO treatment in cerebral ischemia may depend
on the treatment window and treatment duration which
remain less explored. The goal of this study was to use
quantitative MRI to longitudinally evaluate the effects
of NBO in early pre-reperfusion treatment window (60 &
90 min reperfusion post MCAO) with varying NBO treatment
duration (25 min & 50 min respectively). We conclude
that NBO treatment along with reperfusion treatment
reversed ADC lesion and salvaged tissue, and that longer
treatment up to 50 min was more effective. We showed
that NBO not only buy time and expand the treatment
time window, but also that in pre reperfusion treatment
window longer NBO treatment duration further salvages
more tissues.
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