Data-driven analysis of Cerebrovascular reactivity reveals regional vascular impairment in individuals with multiple systemic risk factors
Ekaterina Tchistiakova 1,2 , David E. Crane 2 , Sandra E. Black 2,3 , and Bradley J. MacIntosh 1,2
Medical Biophysics, University of Toronto,
Toronto, ON, Canada,
and Stroke Foundation Canadian Partnership for Stroke
Recovery, Sunnybrook Research Institute, Toronto, ON,
of Medicine, Division of Neurology, University of
Toronto, Toronto, ON, Canada
Cerebrovascular impairment is a common complication in
individuals with cerebral small vessel disease (SVD).
The presence of systemic conditions such as diabetes and
hypertension can further hinder the maintenance of
cerebral blood flow, thereby increasing the risk of TIA
and stroke. In this study we examined the effects of
systemic risk factors on cerebrovascular function,
assessed using vascular reactivity metric (CVR), in
individuals with SVD in regions associated with specific
resting state networks. CVR decrease was associated with
increased number of risk factors within the
sensory-motor and default mode networks.
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