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Abstract #4775

Data-driven analysis of Cerebrovascular reactivity reveals regional vascular impairment in individuals with multiple systemic risk factors

Ekaterina Tchistiakova 1,2 , David E. Crane 2 , Sandra E. Black 2,3 , and Bradley J. MacIntosh 1,2

1 Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2 Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, 3 Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada

Cerebrovascular impairment is a common complication in individuals with cerebral small vessel disease (SVD). The presence of systemic conditions such as diabetes and hypertension can further hinder the maintenance of cerebral blood flow, thereby increasing the risk of TIA and stroke. In this study we examined the effects of systemic risk factors on cerebrovascular function, assessed using vascular reactivity metric (CVR), in individuals with SVD in regions associated with specific resting state networks. CVR decrease was associated with increased number of risk factors within the sensory-motor and default mode networks.

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