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Abstract #4765

Quantitative Study of Longitudinal Relaxation Rate Change in the Transient MCAO Rat Brain

Xiao Wang 1 , Afshin A Divani 2 , Xiao-Hong Zhu 1 , Jessica Nordberg 2 , Julian Tokarev 2 , Yi Zhang 1 , and Wei Chen 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States, 2 Neurology, University of Minnesota, Minnesota, United States

The longitudinal relaxation rate (time) R1 (T1) is a crucial physical property which could guide the choice of imaging parameters and its alteration of tissue is also closely related to the underlying pathology of variety of diseases. This study aims to quantitatively investigate the R1 change of the rat brain tissue subsequent to the middle cerebral artery occlusion (MCAO) on day 1 and day 7 after a 1-hour occlusion, and to examine CBF contribution to the brain tissue R1 alteration. The results show that the R1 in the varied lesion area decreases about 6-25% of its contralateral control and the R1 decrease is mainly dominated by the brain tissue property alteration. In addition, R1 shows statistic difference among varied lesion region while no statistic significant difference is found among baseline CBF on both day 1 and day 7 of post-occlusion, indicating that the R1 images are potentially more sensitive to the extent of lesion than CBF images. The quantified T1 (or R1) image is an important imaging modality and should provide a noninvasive, sensitive and reliable way to help determining the tissue damage caused by ischemic cerebrovascular diseases.

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